Handout 2 Student edition

Handout 2 Student edition - Handout 2 G Protein coupled...

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Handout 2 G Protein coupled receptors : Different types of G protein coupled Receptors G alpha S: s stands for ______ When receptor is active it activates _________ AC converts ATP into cyclic _________ cAMP activates PKa which phosphorlates enzymes Signal amplification: One activated g protein can go activate others How to stop signaling: 1. Turn off the receptor 2. Remove cAMP a. ___________________ convets cAMP into AMP 3. Remove phosphate group from enzymes a. phosphatases What happens if this stopping system doesn’t work? Get a large response, cannot turn off the response Example is Cholera: toxin catalyzes ADP ribosulation of the G alpha subunit inhibiting its GTPase activity. G Protein will be on all the time causes increase in cAMP which open Chloride channels causing Cl to leak out into intestine. Na will follow so will water. Causes diarrhea -> dehydration -> may cause death G alpha i: I stands for _______ Activated in the same way as Gs protein but it just has the opposite effect. Activated Gi -> decreases AC -> Decreases cAMP -> decrease pKa
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Handout 2 Student edition - Handout 2 G Protein coupled...

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