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Unformatted text preview: BICD 150 – Summer 2011 Ni Mo Week 2: Handout #2 [email protected] Material Covered: Thyroid Hormone OH: Tuesday 1-2pm Peterson Hall Lobby Thyroid Hormones Synthesis Diagram: Process:- Iodine is absorbed in the GI tract, and usually converted to iodide. Iodide entry is coupled with entry of 2 Na + ions through a channel called sodium-iodide synport. Once inside the cell, the iodide proceeds to diffuse into the colloid.- 3 Na + is then pumped out of follicular cell against its concentration gradient in exchange for 2 K + pumped in through a Na + /K + ATPase. - Thyroid hormones are synthesized through iodination of amino acid __________________ at carbons 3 and 5. - Tyrosine residues are located on the protein called _________________. This protein is first synthesized in the rough ER of thyroid follicular cells, and then processed in the Golgi apparatus. Afterwards, it is secreted into the colloid, where its residues will be iodinated....
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This note was uploaded on 04/06/2012 for the course BICD 150 taught by Professor Fortes during the Winter '09 term at UCSD.
- Winter '09