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Unformatted text preview: BICD 150 – Summer 2011 Ni Mo Week 2: Handout #1 [email protected] Material Covered: Lectures 1 & 2 OH: Tuesday 1K2pm Peterson Hall Lobby Types of Signals Paracrine: local secretions that influence nearby cells Autocrine: secretions where it binds to receptors in membrane of same cell Juxtacrine: secretions that influence adjacent cells Endocrine: secretions by ductless glands Exocrine: secretions into ducts that leads to outside of body Types of Hormones Proteins and Peptides K Can they be stored? ( Yes /No) K Where are receptors located? ( On membrane /Inside cell) K Duration of effect? ( Short /Long) Steroids K Can they be stored? (Yes/ No ) K Where are receptors located? (On membrane/ Inside cell ) K Duration of effect? (Short/ Long ) Fatty Acid Derivatives – example: eicosanoids K Precursor for eicosanoids: __ arachidonic acid ___, which is the result of either cleaving phospholipid by the enzyme __ phospholipase A2 __ or cleaving DAG by lipase. K AA can react with different enzymes and get converted to different products: o 5Klipoxygenase ! __ leukotrienes ___ o Cyclooxygenase ! _ PGG2 ___ K PGG2 can then be converted to PGH2 via peroxidase. PGH2 can then become PGE2, prostacyclin, or thromboxane. K Most eicosanoid receptors are membrane bound and coupled to GKproteins. K Like steroids, eicosanoids are not stored in cells either, and are synthesized as required....
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This note was uploaded on 04/06/2012 for the course BICD 150 taught by Professor Fortes during the Winter '09 term at UCSD.
- Winter '09