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Unformatted text preview: BICD 150 Endocrinology Mahyar Lotfi Handout #1 Types of Secretions-Endocrine: cell secretes the hormone, and the hormone enters blood circulation- Paracrine: cell secretes hormone that affects adjacent cells, local secretion- Autocrine: secretion that affects the cell that produces the hormone self-stimulation- Intracrine: a type of autocrine, hormone acts within the cell Difference between hydrophilic and hydrophobic hormones* Hydrophilic (water soluble) Hydrophobic (lipid soluble)-AA derivatives, peptide/protein hormones-circulate in free, unbound form-cannot diffuse across the PM -binds with membrane receptor- fast, shorter effects-thyroid and steroid hormones-circulating bound to a carrier-easily diffuse across the PM-binds to cytosolic or nuclear receptors exception: -slow, longer effects Hormone-Receptor Interactions H + R HR @equilibrium: [H][R] kon = [HR] koff Dissociation constant = Kd = With a low koff, Kd increases/decreases (circle one) and gives high/low affinity (circle one)...
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- Winter '09