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Unformatted text preview: TA: Ishita Desai OH: Th 10-11 Café Roma Section: Th 9-9:50am Center 217A [email protected] Handout #1 – TA Version There are various hormones released from various glands/groups of cells within the body. We discussed four different types of hormones in class. Differentiate between the types of signaling in the table below: Type of Signaling Explanation Endocrine Spread through the entire body (requires high affinity receptors because they become diffuse as they spread) Paracrine Released and act locally (ex. Histamine, prostaglandins, etc.) Autocrine Released by and stimulate the same cells Juxtacrine Cell has signal attached to receptor extracellularly (ligand-bound receptors can stimulate cell adjacent to it) Differentiate between the types of hormones in the table below: Type of Hormone Derived/Made From Receptor Location Examples Protein Proteins! Plasma Membrane Insulin, TRH, ACTH, etc. Catecholamine Tyrosine Extracellular (GPCR) Dopamine, norepinephrine, epinephrine Steroid Cholesterol Intracellular Progesterone, estradiol, cortisol, testosterone, etc. Thyroid Tyrosine Intracellular (nuclear) T3, T4 Hormone-Receptor Interactions Hormone + Receptor ↔ HR Complex- The forward reaction has a rate constant known as K on . For the reverse reaction, it’s known as K OFF .- K D , the dissociation constant, is the concentration at with ½ the receptors are occupied....
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- Winter '09
- Hormone binds receptor, high affinity receptors, Antix