Handout 1(1)

Handout 1(1) - BICD 150 Summer 2011 Mo Week 2: Handout #1...

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Ni Mo Week 2: Handout #1 jeffnimo@gmail.com OH: Tuesday 1-2pm Peterson Hall Lobby Types of Signals Paracrine: Autocrine: Juxtacrine: Endocrine: Exocrine: Types of Hormones Proteins and Peptides - Can they be stored? (Yes/No) - Where are receptors located? (On membrane/Inside cell) - Duration of effect? (Short/Long) Steroids - Can they be stored? (Yes/No) - Where are receptors located? (On membrane/Inside cell) - Duration of effect? (Short/Long) Fatty Acid Derivatives – example: eicosanoids - Precursor for eicosanoids: ______________________, which is the result of either cleaving phospholipid by the enzyme _____________ or cleaving DAG by lipase. - AA can react with different enzymes and get converted to different products: o 5-lipoxygenase _________________ o Cyclooxygenase ___________ - PGG2 can then be converted to PGH2 via peroxidase. PGH2 can then become PGE2, prostacyclin, or thromboxane. - Most eicosanoid receptors are membrane bound and coupled to G-proteins. - Like steroids, eicosanoids are not stored in cells either, and are synthesized as required. Hormone-Receptor Interaction Reaction: Hormone + Receptor ↔ H-R complex - The forward reaction has a rate constant _____, while the reverse reaction has rate constant _____. - The dissociation constant _____ is the concentration at which half of the receptors are occupied o K D = k off /k on = [H][R]/[HR] - Receptors with lower K D values will have _____________ affinity. Therefore, compared to that of hormones, antibodies will have _________ K D while neurotransmitters will have ____________ K D Agonists – bind to active site and activate receptor Antagonists – binds to receptor but does not activate it. This blocks agonists from binding Winter 2010 Midterm Question: A drug company is testing two hormone antagonists they synthesized: “Antix 1” and “Antix 2” to see which one will bind to the receptor at lower concentrations than the normal hormone. They measure the rate constants for association and dissociation to and from the hormone receptor The results: Antix 1 binds 2 times faster and dissociates 4 times slower than the normal hormone. Antix 2 binds 8 times faster and dissociates 8 times slower than the normal hormone. a. Write the equation that they will use to calculate the K D values for the antagonists compared to the hormone: b. How will the K D values for Antix 1 and Antix 2 compare with the K D value of the hormone (larger, smaller, or the same)? Antix 1:
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This note was uploaded on 04/06/2012 for the course BICD 150 taught by Professor Fortes during the Winter '09 term at UCSD.

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Handout 1(1) - BICD 150 Summer 2011 Mo Week 2: Handout #1...

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