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ho8 - Pancreatic Hormones Insulin(aka hormone of “FED”...

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Unformatted text preview: Pancreatic Hormones Insulin (aka hormone of “FED” state): promotes anabolism-secreted by beta cells-Stimuli: [glucose] > 80-100mg/dL ↑parasympathetic activity ↑amino acids ↑glucagon ↑GLP-1(glucagon-like peptide 1) , GIP-Inhibition Glucose < 80-100mg/dL ↑sympathetic stimulation via adrenergic receptors-Transduction pathway: Insulin receptor (GF receptor) – Tyrosine kinase mediated signal transduction Insulin responses substrates (SH2, SH3 domains) activation downstream metabolic and mitogenic effects-Effects:-mechanism of insulin secretion: Glucagon (aka hormone of “FASTED” state): stimulates catabolism-secreted by alpha cells-Stimuli: ↓ glucose ↑sympathetic stimulation-Inhibition: ↑glucose, insulin, somatostatin-Effects: Somatostatin-secreted by δ or D cells-inhibits glucagon secretion-acts paracrine-also secreted by hypothalamus (inhibit GH secretion) and stomach Diabetes Mellitus a “tantalizing”disease - cells are surrounded with lots of glucose, but they cannot take up or...
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ho8 - Pancreatic Hormones Insulin(aka hormone of “FED”...

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