SS2 Handout 2

SS2 Handout 2 - TA: Megan Simpkinson [email protected]..

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TA: Megan Simpkinson [email protected] Handout 2 Topics: Thyroid and Thyroid Hormones; Hypo and Hyperthyroidism Thyroid Structure: Note: rT3 or reverse T3 is an inactive form of T3. Generated in peripheral tissues as a method of getting rid of excess T3 by deiodinase converting T4 to rT3. Regulation of Secretion TSH causes growth of the thyroid, increased activity of the NIS, increased thyroglobulin (TGB), and increased thyroperoxidase (TPO), stimulates endocytosis of TGB, increases release of T3 and T4 Synthesis and Secretion 1. I - trapping 2. TGB Synthesis 3. Secretion of TGB into follicle 4. “Organification”—iodination of Tyr residues on TGB to give MIT & DIT (mediated by TPO) a. Linking of DIT + MIT=T3 or DIT +DIT= T4 (also mediated by TPO) 5. Pinocytosis of Iodinated TGB 6. Fusion w/ Lysosomes 7. Proteolysis of TGB, releasing T3 & T4
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TA: Megan Simpkinson [email protected] Actions Thyroid hormones have nuclear receptors cause changes in protein synthesis Promote growth, development
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This note was uploaded on 04/06/2012 for the course BICD 150 taught by Professor Fortes during the Winter '09 term at UCSD.

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SS2 Handout 2 - TA: Megan Simpkinson [email protected]..

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