SS2 Handout 3 - Megans Monday Sections BICD 150 Handout 3...

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Megan’s Monday Sections BICD 150 Handout 3 Topics: Male Reproduction, Steroid Hormones Male Reproduction Anatomy and Histology In the testes: Leydig Cells (aka the interstitial cells) o LH receptors o Produce testosterone Converted to DHT by 5-alpha-reductase Converted to estradiol by aromatase Sertoli Cells (aka secretory cells) o FSH receptors
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o Secrete androgen binding protein, which maintains the high concentration of the androgens around the developing sperm o Secrete inhibin, which inhibits secretion of FSH Sperm production: spermatagonia spermatocytes spermatids spermatozoa o Spermatagonia begin to mature with aid from testosterone and Sertoli cells Mechanism of erection: o Ach endothelial cells Ach mAchR increase in Ca 2+ increase in NOS increase in NO increase NO in smooth muscle guanylyl cyclase stimulated GTP cGMP relaxation of smooth muscle vasodilation erection o Viagra: Prevents the breakdown of cGMP to GMP by Phosphodiesterase 5 (PDE 5) Hypothalamic-Pituitary-Testes Axis: Hormonal Regulation Hypoth: pulses (every 30-120 min) of GnRH starting at puberty ant. Pit.:
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