SS2Handout6

SS2Handout6 - BICD 150 Summer Session 2 Handout 6 TA: Megan...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
BICD 150 Summer Session 2 Handout 6 TA: Megan Simpkinson Insulin: Transduction Pathways -Mitogenic and growth effects Fig.18-5 in Endo text -Metabolic effects: increase glucose uptake: skeletal muscle, adipocytes, liver; increase glycolysis; increase aa uptake; increase protein synthesis; increases lipogenesis Insulin effects: increase glycogen synthase increase glucokinase (hexokinase) increase aa uptake, protein synthesis increase lipoprotein lipase, lipid synthesis decreases hormone sensitive lipase in adipocytes Glucose tolerance tests Patient is given 75g of glucose and their blood glucose levels are monitored Normal pancreatic function--> just a slight peak after administering glucose, drops quickly back to normal fasting levels T1 diabetes mellitus--> fasting levels will already be high prior to glucose administration, could be very high, at levels of 300 mg/dL or even higher T2 diabetes mellitus--> fasting levels will be 120mg/dL or higher, but should not be as high as T1DM patient. Levels may spike to above 200mg/dL after glucose is administered. Metabolic syndrome--> fasting levels will be normal, but their blood glucose levels will spike higher and remain high for a longer period of time than normal. Administering the glucose intravaneously and orally results in different effects due to the incretins. There is increased insulin secretion for oral tests, resulting in a quicker return to normal levels after the glucose is administered. Diabetes mellitus: type 1 and 2 Type 1 autoimmune attack destroys the beta cells of the pancreas--> little to no insulin is produced endogenously therefore, reliant upon insulin from shots or an insulin pump
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 04/06/2012 for the course BICD 150 taught by Professor Fortes during the Winter '09 term at UCSD.

Page1 / 4

SS2Handout6 - BICD 150 Summer Session 2 Handout 6 TA: Megan...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online