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Week 2 Handout Answers

Week 2 Handout Answers - Week 2 Handout TA Manely Leilah...

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Week 2 Handout TA: Manely Leilah Yafeh NOTE: The answers do not and cannot substitute for section attendance. I purposely provide only brief and minimal answers to the handouts to ensure section attendance. If you do not understand any of the answers, then refer to the Study Guide or e-mail me. 1. Compare and contrast the Growth Factor Receptor transduction mechanism with that of the Cytokine Receptor. What are the main differences? Both receptors are from the Receptor Tyrosine Kinase Family. The Growth Factor receptor bears an intrinsic catalytic activity to autophosphorylate its tyrosine residues, whereas the Cytokine recptor must recruit JAK, a soluble tyrosine kinase from the cytosol to phosphorylate its residues. The growth factor receptor is found in a monomeric form in the steady state, whereas the cytokine receptor is found in the dimeric form. The Growth Factor receptor uses soluble G proteins (Src family with SH domains) to transducer the signal whereas the Cytokine receptor uses the JAK-STAT pathway. Refer to the Study Guide for further details.
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