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Week 3 Handout Answers

Week 3 Handout Answers - Week 3 Handout TA Manely Leilah...

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Week 3 Handout TA: Manely Leilah Yafeh NOTE: The answers do not and cannot substitute for section attendance. I purposely provide only brief and minimal answers to the handouts to ensure section attendance. If you do not understand any of the answers, then refer to the Study Guide or e-mail me. 1. What signal allows for milk production and letdown after the birth of the baby? How does this relate to the inhibition of milk production and decreased serum prolactin levels after the baby is weaned? During pregnancy, the high concentration of growth hormone, cortisol, estrogen, and progesterone act permissively to promote PRL secretion. However the elevated concentration of these hormones, especially, progesterone and estrogen, act selectively in that they promote PRL’s development of the glandular structure of the mammary glands, while simulataneously inhibiting milk production. Once the baby is born, the internal stimulus for PRL secretion is removed and PRL secretion becomes solely dependent upon the baby suckling. 2. Why does a lactotroph adenoma result in galactorrhea and amenorrhea? A lactotroph adenoma is a tumor of the anterior pituitary cells that secrete PRL. It results in galactorrhea due to increased milk production and amenorrhea due to GnRH inhibition.
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