Week 4 Handout Answers

Week 4 Handout Answers - Week 4 Handout TA Manely Leilah...

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Week 4 Handout TA: Manely Leilah Yafeh 1. Describe the mechanism of TH synthesis. Draw a diagram to illustrate your answer. Step 1: The Iodide Trap a) Na+/K+ Pump—establishes Na+ gradient b) NIS--Secondary Active Transport c) Pendrin—Basolateral Iodide Channel Step 2: Tg and TPO synthesis a) Nuclear transcription b) Translation and protein secretory pathway c) Exocytosis into colloid Step 3: Iodination of Tyrosine Residues a) TPO redox reaction 1) Oxidize iodide; reduce H 2 O 2 2) Iodinate tyrosine residue a) once=MIT b) twice=DIT Step 4: Coupling Reactions a) MIT + DIT=T3 (5%) b) DIT + DIT=T4 (95%) 2. What is reverse T 3 ? What is its significance? Biologically inactive TH because can’t bind to TH receptor; Produced via 5 deiodinase; rT 3 is significant because it represents a method of TH regulation 3. Name and characterize the three types of TH carrier proteins. What phenomenon regulates TH release from the carrier protein? Binding Equilibria as in the law of mass action regulates TH release from carrier protein
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This note was uploaded on 04/06/2012 for the course BICD 150 taught by Professor Fortes during the Winter '09 term at UCSD.

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Week 4 Handout Answers - Week 4 Handout TA Manely Leilah...

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