Week 4 Handout Answers

Week 4 Handout Answers - Week 4 Handout TA Manely Leilah...

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Week 4 Handout TA: Manely Leilah Yafeh 1. Describe the mechanism of TH synthesis. Draw a diagram to illustrate your answer. Step 1: The Iodide Trap a) Na+/K+ Pump—establishes Na+ gradient b) NIS--Secondary Active Transport c) Pendrin—Basolateral Iodide Channel Step 2: Tg and TPO synthesis a) Nuclear transcription b) Translation and protein secretory pathway c) Exocytosis into colloid Step 3: Iodination of Tyrosine Residues a) TPO redox reaction 1) Oxidize iodide; reduce H 2 O 2 2) Iodinate tyrosine residue a) once=MIT b) twice=DIT Step 4: Coupling Reactions a) MIT + DIT=T3 (5%) b) DIT + DIT=T4 (95%) 2. What is reverse T 3 ? What is its significance? Biologically inactive TH because can’t bind to TH receptor; Produced via 5 deiodinase; rT 3 is significant because it represents a method of TH regulation 3. Name and characterize the three types of TH carrier proteins. What phenomenon regulates TH release from the carrier protein?
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