Week 8 - Inhibitors of secretion Increase glucose Insulin...

Info icon This preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon
Week 8 Handout [email protected] Incretins GLP1 -> inc insulin GIP -> inc insulin Intestinal cells Effects of insulin Increase of glucose uptake in adipose tissue, skeletal muscle.  Due to insertion of GLUT 4 into membrane Liver also takes up glucose but dosent use GLUT 4, uses Hexokinase activity instead.  Decreases concentration of glucose inside cell by converting the glucose into G6P. thus  maintaining a glucose concentration gradient Increases metabolism of glucose anabolic effects Increase glycogen synthesis -> increase glycogin Decrease glycogen phosphorolase Inc tryglicerides Inc amino acid uptake and proteins synthesis Decrease hormone sensitive lipase Decrease beta oxidation pathway End products of beta oxidation is ketoacids  Ketoacidosis breath will smell like apples Inhibition of gluconeogensis  Glucagon Stimulants of secretion Decrease glucose Increase sympathetic activity
Image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 2
Image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 4
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Inhibitors of secretion Increase glucose Insulin Somatostatin Incretins Parasympathetic stimulation Effects of glucagon Inc glycogen phosphorylase -> inc G1P -> Inc G6P Inc G6P phosphatatse -> Glucose In muscle there is no g6p phosphatate, so it has to reuse it or convert it into lactic acid and release into circulation Liver can convert lactic acid back into glucose Inc gluconeogenisis Inc hormone sensitive lipase – releasing fatty acids and glycerol into circulation Inc proteolysis – releasing proteins to be metabolized Diabetes Melletus Type 1 diabetics Large volume of urine Weight and muscle loss Fasting >126mg/dl Random> 200mg/dl Glu>300mg/dl Inc osmolrity -> polydypsia Thirst Inc unrine osmolarity-> polyurea Polyphagia Polydypsia, polyphagia, polyurea – diabetes type 1 characteristics 22:32 22:32...
View Full Document

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern