Week 8 - Inhibitors of secretion Increase glucose Insulin...

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Week 8 Handout Pvrana@ucsd.edu Incretins GLP1 -> inc insulin GIP -> inc insulin Intestinal cells Effects of insulin Increase of glucose uptake in adipose tissue, skeletal muscle.  Due to insertion of GLUT 4 into membrane Liver also takes up glucose but dosent use GLUT 4, uses Hexokinase activity instead.  Decreases concentration of glucose inside cell by converting the glucose into G6P. thus  maintaining a glucose concentration gradient Increases metabolism of glucose anabolic effects Increase glycogen synthesis -> increase glycogin Decrease glycogen phosphorolase Inc tryglicerides Inc amino acid uptake and proteins synthesis Decrease hormone sensitive lipase Decrease beta oxidation pathway End products of beta oxidation is ketoacids  Ketoacidosis breath will smell like apples Inhibition of gluconeogensis  Glucagon Stimulants of secretion Decrease glucose Increase sympathetic activity
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Unformatted text preview: Inhibitors of secretion Increase glucose Insulin Somatostatin Incretins Parasympathetic stimulation Effects of glucagon Inc glycogen phosphorylase -> inc G1P -> Inc G6P Inc G6P phosphatatse -> Glucose In muscle there is no g6p phosphatate, so it has to reuse it or convert it into lactic acid and release into circulation Liver can convert lactic acid back into glucose Inc gluconeogenisis Inc hormone sensitive lipase releasing fatty acids and glycerol into circulation Inc proteolysis releasing proteins to be metabolized Diabetes Melletus Type 1 diabetics Large volume of urine Weight and muscle loss Fasting >126mg/dl Random> 200mg/dl Glu>300mg/dl Inc osmolrity -> polydypsia Thirst Inc unrine osmolarity-> polyurea Polyphagia Polydypsia, polyphagia, polyurea diabetes type 1 characteristics 22:32 22:32...
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Week 8 - Inhibitors of secretion Increase glucose Insulin...

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