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Unformatted text preview: a of the N-terminal amino group of the alpha-chains. These two N-termini together account for about 30% of the H + portion of the Bohr effect. The majority (approximately 40%) of the H + Bohr effect occurs at the C − terminal histidine (his146) of the beta-chains. The other 30% of the H + Bohr effect occurs at several other residues on hemoglobin. Cl − creates additional salt bridges, favoring the T form of hemoglobin. Chloride would be considered a negative heterotropic allosteric effector. β 2 Asp − His + NH 3 + COO − FG1 HC3 Arg + Asp − α 1 Lys + COO − NH 3 + HC3 H9 C5 Cl − Cl − Lys + α 2 Asp − Arg + NH 3 + COO − C5 H9 HC3 His + Asp − β 1 COO − NH 3 + HC3 FG1 Nelson and Cox, Lehninger Principles of Biochemistry...
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- Fall '08
- Hemoglobin, Protein Data Bank, Salt Bridges, Oxy Hb, H+ Bohr effect