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Unformatted text preview: a of the N-terminal amino group of the alpha-chains. These two N-termini together account for about 30% of the H + portion of the Bohr effect. The majority (approximately 40%) of the H + Bohr effect occurs at the C terminal histidine (his146) of the beta-chains. The other 30% of the H + Bohr effect occurs at several other residues on hemoglobin. Cl creates additional salt bridges, favoring the T form of hemoglobin. Chloride would be considered a negative heterotropic allosteric effector. 2 Asp His + NH 3 + COO FG1 HC3 Arg + Asp 1 Lys + COO NH 3 + HC3 H9 C5 Cl Cl Lys + 2 Asp Arg + NH 3 + COO C5 H9 HC3 His + Asp 1 COO NH 3 + HC3 FG1 Nelson and Cox, Lehninger Principles of Biochemistry...
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- Fall '08