Homework06_KEY

Homework06_KEY - 3. (16 pts.) Rushi, a graduate student in...

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3. (16 pts.) Rushi, a graduate student in a UCD research lab, has identified three mutations that cause zebrafish germ cells (the cells that produce sperm and eggs) to die, thus resulting in sterile fish. His complementation analysis indicated that all three mutations are in the same gene. After determining the location of the gene by mapping, Rushi sequenced the wild-type allele and found that it contained a single intron, and can encode a protein of 356 amino acids. a. (2 pts.)What is the minimum number of nucleotides in the protein-coding part of this zebrafish gene? Show your work. a. (356 aa)(3 bp/aa)=1,068 basepairs b. (6 pts.) Rushi sequenced the three mutant alleles and found that in each case, he could find a single nucleotide difference between the wild-type allele and the mutant allele. For two of the alleles, DNA base pair changed localized to the predicted protein coding sequence. Name two different types of mutations that
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Homework06_KEY - 3. (16 pts.) Rushi, a graduate student in...

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