Lecture05-S11

Lecture05-S11 - BIS 101-002 12 Apr 08 Allele and Gene...

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BIS 101-002 12 Apr 08 Allele and Gene Interactions
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PKU is pleiotropic phenotype, affecting: -motor capacity -mental capacity -organ function
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QuickTimeª and a decompressor are needed to see this picture. QuickTimeª and a decompressor are needed to see this picture. Forward genetic screen to identify genes required for locomotion in C.elegans Wild-type unc mutant
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Are they mutations in the same gene? Wild-type apricot white ruby
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Complementation Test Conclusion: 5 complementation groups (i.e. 5 genes)
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white and apricot are mutations in the same gene Nulls and hypomorphic alleles Phenotypic series: white > aprico t Conclusion: white = null allele; apricot = hypomorphic allele Wild-type apricot white ruby
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Isolation of arginine auxotrophic mutations George Beadle and Edward Tatum Nobel Prize in Physiology and Medicine, 1958 “For their discovery that genes act by regulating definite chemical events.”
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Lecture05-S11 - BIS 101-002 12 Apr 08 Allele and Gene...

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