Lecture09-S11

Lecture09-S11 - BIS101 Apr 28, 2011 DNA DNA James Watson...

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DNA BIS101 Apr 28, 2011
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DNA
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James Watson and Francis Crick 1962 Nobel Prize in Physiology or Medicine
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Watson and Crick
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Qualities necessary for the structural features of the genetic material: 1. Must have informational content (to encode for proteins) 2. Must allow for faithful replication during each cell division 3. Must have physical and chemical stability 3. Must be able to change (e.g. by mutation- more in Chapter 14 ).
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DNA Melting Curve
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The DNA Double Helix
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How is DNA replicated?
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Three Models for DNA Replication
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Meselson-Stahl experiment (1958)
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Meselson-Stahl experiment (1958)
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Meselson-Stahl experiment (1958)
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Meselson-Stahl experiment (1958)
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The Replication Fork (Cairns, 1963)
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DNA Replication
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The Replisome: A Molecular Machine Helicase: Unwinds DNA to allow replication Topoisomerase: Relaxes supercoiled DNA that is created by the helicase Primase: Synthesizes the RNA primer required for lagging strand DNA synthesis. DNA Pol I:
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Lecture09-S11 - BIS101 Apr 28, 2011 DNA DNA James Watson...

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