Lecture11-S11a - Splice Acceptor Spliceosome Assembly and...

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BIS 101 5 May 11 RNA Transcription
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Regulated Gene Expression in Eukaryotes gene 1 gene 1 Ear Brain Kidney A zebrafish embryo (15 hour post-fertilization)
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Organism Genome Size (Bases) Estimated Genes Genes/ 1 million bp Human ( Homo sapiens ) 3 billion 20-25,000 ~9 Lab mouse ( M. musculus ) 2.6 Billion 29,000 Mustard Weed ( A. thaliana ) 157 million 27,000 ~170 Fruit fly ( D. melanogaster ) 137 million 13,000 ~95 Roundworm ( C. elegans ) 97 million 19,500 Yeast ( S. cerevisiae ) 12.1 million 6,000 Bacteria ( E. coli ) 4.6 million 3,200 ~695 Human immunodeficiency virus (HIV) 9700 9 Genome size and Gene Number
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RNA Transcription and Processing in Eukaryotes
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Eukaryotic DNA is packaged into chromatin
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TFIIH has helicase activity
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Cotranscriptional Processing of RNA
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Cotranscriptional Processing of RNA
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Cotranscriptional Processing of RNA
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Alternative Splicing in Eukaryotes
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Regulation of mRNA Splicing Splice Donor
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Unformatted text preview: Splice Acceptor Spliceosome Assembly and Function PROTEIN Proteins Have Structure 5’ 3’ Colinearity of DNA Mutation and Amino Acid Change The Genetic Code Missense Mutations in Conserved Domains tRNAs and the Anticodon Aminoacyl tRNA Synthetase The Genetic Code The Ribosome A = aminoacyl P = peptidyl E = exit Figure 9-13 Figure 9-14 16S rRNA Figure 9-15 Translation A = aminoacyl P = peptidyl E = exit Translation Initiation (bacteria) (30S Ribosome) Prokaryotes Eukaryotes Figure 9-17 Figure 9-18 Initiation Prokaryotes Eukaryotes Figure 9-19 Elongation Termination Figure 9-21 Nonsense Suppressors Figure 9-23 Alternative splicing produces related, but distinct proteins Protein phosphorylation and dephosphorylation regulates enzyme activity Figure 9-24...
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