101_12AI_renal_1_design

101_12AI_renal_1_design - what are these structures made...

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Unformatted text preview: what are these structures made of? what do they do? how do they operate? RENAL system kidneys form urine ureters passive flow to reservoir bladder urethra collect urine & micturate strategy for studying renal system 1) functions e.g., what problems does it solve? 2) macroscopic & microscopic organization 3) how could you design it? 4) how is it regulated? npb101-w2012-ishida what problems are solved by the renal system? recall lecture #1... a) our bodies are essentially two aqueous solutions ( intracellular & extracellular fluids ) surrounded by a membrane ( body surface ) b) the concentration of water & solutes in our bodies is not the same as that of our environment. problem : a) maintain constant fl uid volume b) maintain constant fluid composition solution : essentially... 1) imagine a 1-gallon bottle of water 2) how much water is in your body? 1) 2.5 gallons? would look like dried prunes 2) 25 gallons? heavier than most of you (25 x 8 = 200 lbs) 1) balance intake versus loss - maintain fluid balance 2) thereafter, water moves passively across membranes: at steady-state, [H 2 O] intracellular = [H 2 0] extracellular how much volume is this & where is it located? 2/3 = intracellular 1/3 = extracellular 20% = blood plasma 80% = interstitial negligible: sweat, lymph, digestive juice, CSF, intraocular fluid total volume where is this water? how can you avoid losing this water? note the answer given in class how do we balance water gain and loss? The renal system controls the largest amount of water loss from the body, by controlling the volume of urine formed by the kidneys . gain loss route quantity route quantity diet liquid food metabolism 1.2 liter 1.0 liter 0.35 liter lungs skin - diffusion skin - sweat feces urine 0.9 liter 0.1 liter (@rest) 0.1 liter 1.5 liter 2.6 liter per day 2.6 liter per day Table 15-3 Water gain is mainly through consumed liquids. Consumption is driven by 2 neural circuits that control a thirst center in the brain ....
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This note was uploaded on 04/05/2012 for the course NPB NPB 101 taught by Professor Weidner/wingfield during the Spring '08 term at UC Davis.

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101_12AI_renal_1_design - what are these structures made...

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