101_12AI_renal_2_filtration

101_12AI_renal_2_filtration - kidneys ureters bladder...

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Unformatted text preview: kidneys ureters bladder urethra renal tubule (tubular component) epithelial cells vascular component 1) 4 major structures: kidneys, ureters, bladder, urethra. 2) retain important chemicals & avoid toxic changes in fluid composition by controlling composition of filtrate & thus our blood. 3) fluid balance achieved largely by balancing fluid intake & urination. nephron renal system glomerular filtration tubular reabsorption tubular secretion excretion urine formation Moffett et al ’93 Human Physiology, fig.19-6 Fig 14-6 put 1 sphaghetti strainer inside another... add 1 small white meatball add 1 large green meatball + which ball moves from blood to filtrate? blood filtrate Fig 14-6 or ... imagine sand vs stones 1) how can it move out of the capillary? 2) how can it move into Bowman’s capsule? 3) what forces influence the rate at which it moves? how can anything move from blood to filtrate? which ball moves from blood to filtrate & why? blood filtrate size fluid pressures concentration gradient blood filtrate 1) pink could pass through 2) green can not 1) white moves toward filtrate 2) pink moves toward blood blood 55 mm Hg filtrate 15 mm Hg 1) MAP 55 mm Hg 2) initial filtrate fluid pressure 15 mm Hg 3) osmotic pressure initially, blood would tend to push fluid into Bowman’s capsule blood filtrate charge weak negative charges @ basement membrane - - - - - glomerular ‘filters’ 1) gaps between endothelial cells of capillaries large gaps ( fenestrae , 70-100 nm) 2) basement membrane (collagen & glycoprotein) negatively charged 3) gaps between podocytes of Bowman’s capsule small gaps ( filtration slits , 25-60 nm) Fig 14-7 1) hold out your right hand, palm up. 2) place a piece of cloth on your palm. 3) curl the fingers of your left hand & place them on top of the cloth. 4) wrap your right hand around the cloth & your left hand. analogy: make a fst with your leFt hand & wrap your right hand round it… 5) the fingers of your left hand are the glomerulus . 6) your right hand is Bowman's capsule . 7) the basement membrane is the cloth sandwiched between the ball of string and the palm of your hand. 8) the endothelial cells form the wall of the glomerular capillary. (obviously, your left fingers are hollow & the blood flows through them.) 9) the epithelial cells form the wall of the renal tubule. (the ones with the filtration slits would be on the surface of the palm of your right hand. net glomerular filtration pressure note: P GC > that in other capillaries because diameter of the efferent arteriole is smaller than that of the afferent arteriole....
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101_12AI_renal_2_filtration - kidneys ureters bladder...

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