Updated notes for respiratory system Lecture 27

Updated notes for respiratory system Lecture 27 -...

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Unformatted text preview: Hypoven(la(on: pCO2 higher, results in higher H+ =lower pH (acidosis) Hyperven(la(on: pCO2 lower, results in lower H+ =higher pH (alkalosis) Fig. 13 ­31, p. 487 Chemical factors that play role in determining magnitude of ven(la(on (keeping the others constant) Slide 6, lecture 27 NOTE ­ challenges made In arterial blood but venBlaBon Is response of the whole system For example, from what I showed you later, varying CO2 is influencing venBlaBon primarily via diffusion into the brain ECF, geKng converted there to carbonic acid, and the resulBng H+ is influencing CO2 has weak sBmulatory effects on both peripheral and central chemoreceptors which is consistent with what is being shown here. It also shows that arterial H+ changes can be sensed directly by peripheral chemorectors but this can come from anything that changes blood pH not just changes in pCO2. Why isn t a fall in PO2 more of a dominant player here? Recall the Hb-O2 dissociation curve….. NOTE: under normal circumstances, the pO2 of the large arteries(where peripheral chemoreceptors are) is close to pO2 at pulmonary capillaries ...
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This note was uploaded on 04/05/2012 for the course NPB NPB101 taught by Professor Weidner during the Spring '08 term at UC Davis.

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