RNA_Supplement_BIOL1010 - RNA Supplement At this point in...

Info icon This preview shows pages 1–26. Sign up to view the full content.

View Full Document Right Arrow Icon
RNA Supplement
Image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
At this point in your careers, you have only been exposed to RNA as mRNA, tRNA, and rRNA. However, RNA is involved in many other process.
Image of page 2
Image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 4
RNA transcription can be regulated (on/off – although there usually is some “leaky” transcription) or it can be constituitive (on all the time). Also, some genes are transcribed at higher rates than others.
Image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Single stranded RNA is less stable than DNA
Image of page 6
But RNA can make double stranded structures (normally within the same chain – foldback) however, the presence of the 2’OH creates a little different helix than that observed in DNA.
Image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Secondary structures of RNA
Image of page 8
Tertiary Structures of RNA
Image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 10
Recognition of promoters in bacteria (like E. coli )
Image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
E.coli promoter sequences – note “Conservation”
Image of page 12
Remember, even though we write Left to Right, RNA polymerase recognizes promoters on either strand and will go in the direction indicated. We present DNA sequences in a 5’ -3’ direction.
Image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Note that not all genes are transcribed in the same direction!
Image of page 14
Image of page 15

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Eukaryotic transcripts often have introns that need to be spliced out by the SPLICOSOME. Than contains various snRNP’s
Image of page 16
Some introns can be “self spliced”.
Image of page 17

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
tRNA structures
Image of page 18
Wobble position has variable base pairing
Image of page 19

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
rRNA and tRNA have modified bases
Image of page 20
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern