MolCellEng_Notes1

MolCellEng_Notes1 - 1 Fundamentals 1 Central Dogma of...

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1. Fundamentals 1. Central Dogma of Biology 1. DNA is transcribed to RNA, which is translated to protein – the transfer of sequential information (statement of Central Dogma of Bio) 2. RNA is needed as an intermediate because: 1. DNA can stay pristine (new, in original condition) and protected, away from caustic chemistry of cytoplasm 2. Can amplify gene info. from many copies of RNA (that was made from one copy of DNA) 3. Can control regulation of gene expression better by having more chances – the more elements in pathway, the more opportunities to control it in different circumstances. 2. DNA’s Four Nucleotide Bases 1. DNA = deoxyribonucleic acid 2. Nucleotide: phosphate + sugar ring + base 3. Purines: adenine & guanine 4. Pyrimidines: Thymine & Cytosine 5. G-C base pairing stronger than A-T base pairing 1. A-T; 2 H- bonds 2. G-C; 3 H- bonds 6. DNA extends from 3’ OH end on; always read from 5’ to 3’ end 7. Sugar ring has 5 carbons, note location of 5’ and 3’ carbon: 5’ carbon has phosphate group attached to it, 3’ carbon has OH group attached to it. 1
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1. Be able to draw sugar ring. 2
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3. Chemistry Review 1. Covalent bonds are strongest – formed by sharing pair of electrons; triple bonds more stable than double bonds, which are more stable than single bonds.
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