Section3-4-1 - 3/20/12 Bitter molecule binds to receptor on...

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3/20/12 1 “Bitter” molecule binds to receptor on microvilli G-protein “activated” Enzyme Makes Second Messenger Release of Ca ++ from intracellular stores (may also let Na + in, like sweet) Release of neurotransmitter Postsynaptic cell. Action potential to brain Approximately 25 different bitter receptor types All seem to converge on common neurons, so no discrimination between bitter compounds Evolutionary signiFcance? Sensitivity to multiple possible toxins and want to avoid the all! Allows for individual differences in sensitivity to particular bitter compounds. Amino acid binds to receptor on microvilli G-protein “activated” Enzyme Makes Second Messenger Several possible ways to increase Ca ++ Release of neurotransmitter Postsynaptic cell. Action potential to brain e.g., MSG • Related to sugar receptor: – Combination of T1R1 and T1R3 • Also an independent receptor for glutamate.
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This note was uploaded on 04/09/2012 for the course EXP 3202 taught by Professor Staff during the Spring '12 term at Florida State College.

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Section3-4-1 - 3/20/12 Bitter molecule binds to receptor on...

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