Section3-2-1 - 3/13/12 Olfactory Transduction Transduction...

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3/13/12 1 Olfactory Transduction • Very sensitive (one molecule can cause depolarization, a few will cause an action potential) • Probably 350-1000 different types of odorant receptors! Transduction process : • Odorant receptors are g-protein coupled receptors • Respond to several different molecules (similar structure) • Lock and key model of activation Genetic basis of olfactory receptors: • Buck and Axel showed that genome contains about 1000 different olfactory receptor genes; each codes for a single type of OR • All mammals have pretty much the same set of 1000 genes. • So why differences in olfactory abilities? – Some genes are non-functional pseudogenes Dogs and mice: About 20% are pseudogenes Humans: Between 60% and 70% are pseudogenes » Each person has a different number of pseudogenes, resulting in individual differences in sensitivity to smells Cilia from different olfactory sensory neurons Each Olfactory sensory neuron has one particular odorant receptor protein in membrane Each odorant receptor detects a portion of odorant molecule Odorant receptor Odorant molecule Each odorant molecule will activate several odorant receptors Shape-Pattern Theory
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This note was uploaded on 04/09/2012 for the course EXP 3202 taught by Professor Staff during the Spring '12 term at Florida State College.

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Section3-2-1 - 3/13/12 Olfactory Transduction Transduction...

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