lecture 4_CAO_330

lecture 4_CAO_330 - Lecture 4 Membranes 1 Key functions...

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1 Lecture 4: Membranes
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2 Key functions Compartmentalizes the cell Provides a selectively permeable barrier. – Not everything crosses the membrane Responds to external signals – Hormones – Stress signals Transduces energy – Mitochondria – Chloroplasts Provides scaffold for biochemical activities – The membrane itself is a compartment – Reaction components can be arranged here to facilitate interactions between them
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3 Membrane The major components in membranes are lipid and proteins.
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4 Outline 1.Structure : fluid mosaic model 2.Chemical composition lipids and proteins. -Methods used to study membranes 3.Membrane lipid properties - Lipid fluidity - Lipid asymmetry - Lipid rafts 4.Dynamic nature of membranes
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5 Model of the Membrane Figure 10-1 Molecular Biology of the Cell (© Garland Science 2008) model (1972) – Fluid-mosaic model – Lipid bilayer is the core of the membrane model (50% of mass) – Proteins make up the rest of the membrane. – The proteins can move freely (diffuse) in the bilayer
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Fluid Mosaic Model 6
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7
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8 Major components in cell membranes (lipid) 1. Phospholipids (phosphoglycerides) 2. Sphingolipids 3. Sterols
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9 (1) Phospholipids Phosphoglyceride: derived from glycerol
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10 Sphingolipid is derived from sphingosine. sphingosine
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lecture 4_CAO_330 - Lecture 4 Membranes 1 Key functions...

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