Cytoskeleton I

Cytoskeleton I - Cytoskeleton and Nucleoskeleton(I Chapter...

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Unformatted text preview: Cytoskeleton and Nucleoskeleton (I) Chapter 16 * * * * Common properties - Made of proteins - Dynamic properties - Form stable structures - Coordinate with internal and external signals Nuclear lamins Green signal: microtubules Red Signal: actin filaments or microfilaments Sometimes called Monomer: G-actin small diameter. alpha and beta heterodimer middle holo. diameter in between. 50 proteins encoding this. Polymers: F-actin. a twist of ! bers. Common properties - Made of proteins - Dynamic properties - Form stable structures - Coordinate with internal and external signals Nuclear lamins Green signal: microtubules Red Signal: actin filaments or microfilaments Sometimes called Monomer: G-actin small diameter. alpha and beta heterodimer middle holo. diameter in between. 50 proteins encoding this. Polymers: F-actin. a twist of ! bers. Signals can make them dynamic and rigid. Rapid Changes in Cytoskeleton Organization during cell division Purple: actin Green: microtubules Microtubules can form mitotic spindle fiber, they are condensed. Interphase Metaphase Anaphase Telophase Actin in the center Actin helps pinching off. Nuclear lamins (located in the nucleus) get dissembled. Nuclear lamins reassembled. Cytoskeletal functions icrofilaments, intermediate filaments icrotubules do these. Cytoskeleton- Outline I. Three major types of filaments form the cytoskeleton network i) actin filaments, ii) microtubules, iii) intermediate filaments II. Principles underlying assembly & disassembly Assembly: i) nucleation, ii) elongation, iii) steady state III. Regulation of cytoskeleton - Accessory proteins: bind actin or tubulin to change assembly or stability - Signaling induces changes in cytoskeletal arrangement, and so change cell behaviour. E.g. cdc42, Rac, Rho Micro ! laments. !" Tubulin dimers Nuclear lamin Actin cytoskeleton G-actin F-actin or barbed end or pointed end monomer polymer 3 things: nucleotide binding site pocket, where ATP stores. Monomer ATP, Polymer ADP....
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Cytoskeleton I - Cytoskeleton and Nucleoskeleton(I Chapter...

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