Microbiology

Microbiology - Selective toxicity o Therapeutic index Mode...

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Discovery of antimicrobial agents Paul Ehrlich o Microscopist Observed that stains could distinguish between bacterial and eukaryotic cells. Hypothesis: Selective Toxicity Search for magic bullet (kill bacteria but not eukaryotic cells) o Chemical treatment of syphilis ~1910 Salvarsan Initiated search for treatments of infectious disease o This is a chemotherapeutic agent Alexander Fleming o Studying the growth of bacteria o Went away on vacation o Observed growth inhibition o Hypothesis: Fungus producing antimicrobial product o Discovery of Penicillin Properties of antimicrobial agents
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Unformatted text preview: Selective toxicity o Therapeutic index Mode of action Spectrum of Activity o Broad v. Narrow Biological half-life Mechanisms of Action Target biological processes o Cell Wall o Cell membrane o DNA Synthesis o RNA synthesis o Protein Synthesis o Metabolism Each bacteria has a specific target Implications of antibiotic treatment Bactericidal Bacteriolytic Bacteriostatic Antiviotic interactions Synergy o Sum of two is greater than sum of each o TB Additive Antagonistic...
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This note was uploaded on 04/07/2008 for the course BSCI 223 taught by Professor Stein during the Spring '08 term at Maryland.

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Microbiology - Selective toxicity o Therapeutic index Mode...

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