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Lecture 2

0 pka 105 imidazole table 32 know the pka values of

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Unformatted text preview: pKa. Tyrosine pH Ratio ( unprot: prot) 9.5 1:10 10.5 1:1 11.5 10:1 alkylamino group pKa = 12.5 guanidino group pKa = 3.9 pKa = 4.1 dicarboxylic acids uncharged but highly polar Ionization of H istidine (a) Titration curve of histidine pK1 = 1.8 pK2 = 6.0 pK3 = 9.3 pI = pH at which net charge is zero pI = (6 + 9.3)/2 =7.65 To determine the p I: pick the pKa a bove & below point where charge is zero and average those 2 p Ka’ s 5...
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