The role of the basal ganglia in learning and memory- Evidence from Parkinson's disease.pdf

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Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
THE ROLE OF THE BASAL GANGLIA IN LEARNING AND MEMORY:EVIDENCE FROM PARKINSON’S DISEASE By Daphna ShohamyA dissertation submitted to the Graduate School-Newark Rutgers, The State University of New Jersey in partial fulfillment of requirements for the degree of Doctor of Philosophy Graduate Program in Behavioral and Neural Science Written under the direction of Dr. Mark A. Gluck and approved byNewark, NJMay, 2003Reproduced with permission of the copyright owner. Further reproduction prohibited without permission.
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AbstractParkinson's disease, well known for its disruptive effects on movement, also affects cognitive function and leads to a variety of learning and memory deficits. Currently, there is no clear understanding of the precise nature of these deficits, nor of their neural basis. The studies presented here examined learning and memory deficits in patients with Parkinson's disease, with two main goals. First, we sought to provide a more detailedunderstanding of the nature of learning and memory impairments in Parkinson's disease.To that end, the present studies developed tasks and analyses that assessed strategies involved in the learning process. These studies revealed that Parkinson’s patients are specifically impaired at complex, integrative learning strategies, while simpler learning strategies remain intact. The second main goal of the present studies was

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