Protein tyrosine phosphatases can remove the

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Unformatted text preview: Disheveled (inhibits S/T kinase) Hedgehog/patched Smoothened (inhibits S/T kinase) TNF/TNF receptors serine threonine kinase Delta/Notch protease (MulAple)/Receptor Tyrosine Kinases* Tyrosine kinase *Note: There are also non ­receptor tyrosine kinases, like src. Binding of dimerized signaling molecule (e.g. EGF, FGF, NGF, stem cell factor) promotes dimerizaEon and acEvaEon of the RTK. This is a point of control for direcAng different cells to respond differently to similar signals. The acEve RTKs can be inacEvated in two ways. Protein tyrosine phosphatases can remove the phosphates or endocytosis can remove the acEve receptors from the cell surface. Figure 16-30 Essential Cell Biology (© Garland Science 2010) 9 3/13/12 Binding to adaptor proteins and guanine nucleoEde exchange factors leads to the acEvaEon of the monomeric GTPase Ras, which then acEvates downstream...
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