How do dierent cells come to express dierent genes

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Unformatted text preview: at makes cells different? Differen3al Gene Expression How do different cells come to express different genes? Two components of differen3al gene expression: What is the nature of the switches that turn genes on or off and keep them on or off? What are the events that turn parAcular switches on or off? Gene regula3on TranscripAonal and pospranscripAonal controls Developmental events: Asymmetric divisions Localized cytoplasmic determinants Cell signaling Morphogen gradients 13 3/25/12 Central quesAons in Developmental Biology: 1.  How do different cells come to express different genes? Developmental events and gene regula3on 2.  How do cells come to be different in an organized and reproducible way? How do cells come to be different in an organized and reproducible way? Head Anterior, cephalic Belly ventral Back dorsal Tail Posterior, caudal Regional SpecificaAon/Axis formaAon 14 3/25/12 How do cells organize into 3ssues and organs? Frog gastrulaAon & neurulaAon Limb development Branching in kidney Morphogenesis How do similar cell types organize into different shapes and paSerns? Arm – bone muscle carAlage ligaments tendons nerves skin ≠ PaSern Forma3on Leg – bone muscle carAlage liga...
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