Class 4 - History of Epidemic Disease, Germ Warfare, and Anthrax (Epidemiology) I. History of disease - the Black Death A. Overview --caused by bacillus Yersinia pestis --a disease of rats spread to humans by fleas 1. Acute infection caused by bacillus Yersinia pestis, known as the Black Death, Bubonic Plague, Great Plague 2. Primarily a disease of rats and other rodents and is usually spread to human beings by flea bites 3. 3 "pandemics" wiped out large proportions % of populations (when total populations were smaller) --400-500 AD Rome; 1347-1665 Europe – killed 33-50% of population; 1896-1933 Asia B. Bubonic plague in medieval Europe (1347-1665) – episodic and unpredictable --75% of children died before the age of 10 1. Symptoms --attack lymph nodes; black spots on the skin; no immunity developed 2. Medieval treatment totally ineffective --believed to be caused by imbalance of 4 humors—black bile, yellow bile, blood, phlegm
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- Fall '07
- Bubonic Plague, streptomycin, Germ Warfare