Chapter_23_immune_System-1 - Chapter 23 Immune System 23.1 Anatomy of the Immune System Leukocytes o Phagocytes o Lymphocytes o Mast Cells and Dendritic

Chapter_23_immune_System-1 - Chapter 23 Immune System 23.1...

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Chapter 23: Immune System 23.1 – Anatomy of the Immune System Leukocytes o Phagocytes o Lymphocytes o Mast Cells and Dendritic Cells Lymphoid Tissues 23.2 – Organization of the Body’s Defenses Nonspecific Defenses o Physical Barriers o Inflammation Phagocytosis of Pathogens and Debris by Nearby Macrophages Dialation and Increased Permeability of Capillaries Containment of Foreign Matter Leukocyte Migration and Proliferation Continued Clearing of Infection by Recruited Leukocytes o Interferons o Natural Killer Cells o The Complement System Specific Defenses: Immune Responses o Features of Immune Responses Specificity Diversity Memory Self-tolerance 23.3 – Humoral Immunity The Role of B Lymphocytes in Antibody Production Antibody Function in Humoral Immunity o Neutralization o Agglutination o Opsonization o Complement Activation o Enhanced Activation of Natural Killer Cells 23.4 – Cell-Mediated Immunity Roles of T Lymphocytes in Cell-Mediated Immunity o MHC Molecules: Markers of Self o The Role of MHC Molecules in T Cell Maturation o The Role of MHC Molecules in Antigen Presentation and T Cell Activation Helper T Cell Activation Cytotoxic T Cell Activation: The Destruction of Virus-Infected Cells and Tumor Cells 23.5 – Immune Responses in Health and Disease Generating Immunity: Immunization Roles of the Immune System in Transfusion and Transplantation o Blood-Group Compatibility o Tissue and Organ Transplantation Immune Dysfunctions o Allergy o Autoimmune Diseases o Immunodeficiency Diseases o The Role of Stress in the Immune Response 23.1 – ANATOMY OF THE IMMUNE SYSTEM LEUKOCYTES o Phagocytes o Lymphocytes B Cells B cells associated with antibodies B cell contacts antigen plasma cell
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Plasma cell secretes antibodies (immunoglobulins) Antibodies mark invaders for destruction T Cells Directly damage foreign cells T cells contact infected, mutant or transplanted cells Develop into cytotoxic T cells that destroy target cell o Takes several days o Secretory products form pores in target cell membrane o Lysis Null Cells Most are natural killer cells Important against viral infections Attack virus-infected cells – cause lysis o Attack your own cells that have a virus inside them o Blowing up your own cells Fast acting – early immune response Act in a non-specific manner o Go after any cell LYMPHOID TISSUES o Two types: Central Lymphoid Tissue: Bone marrow Thymus Peripheral Lymphoid Tissue Spleen Lymph nodes Tonsils Adenoids Appendix Peyer’s patches o Central Lymphoid Tissue Bone marrow Hematopoietic stem cells: precursor for all blood cells Leukocytes except T lymphocytes fully develop Thymus T lymphocytes migrate from bone marrow to thymus o Develop maturity in thymus Maturity – the ability to tell self from non self o
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  • Spring '07
  • Bourgeious
  • cells, Cytotoxic T cells

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