Lecture 25 0426 2012_class

Studies of gene expression profiles in studies

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Unformatted text preview: e. 2. ID of genes which are strongly implicated ID in inflammatory disorders. Protein Arrays Protein New challenges in our relationship to viruses, bacteria, and parasites bacteria, Challenge to the immune system Challenge Rapid growth of the human population Crowding together in large cities High-speed, efficient means of travel Examples: 1992 Examples: Consequences Consequences The immune system no longer enjoys the luxury of time New microbes come into being – HIV Old pathogens invent new tricks – drugresistant tuberculosis Will we continue to coexist? Will we survive? Answers Answers Our immune system is intensely polymorphic The human immune system is now evolving The more rapidly than ever before more Most of this change effects genes that express Most many different forms of the same MHC or antibody molecule antibody These molecules vary from one individual to another to such an These extent that a single combination is hardly ever duplicated extent Our parasites breed far more rapidly than we do Our and can therefore evolve more rapidly and Answers (cont.) Answers Challenge: opportunities have never been Challenge: greater for mixing hosts and parasites that have no previous experience of one another no “History”: seldom if ever does it pay a parasite History”: to kill its host to Our best defense is immune system’s Our polymorphism polymorphism All of the existing structures of our immune All defense were anticipated in earlier forms of life. There is no sign that new ones will emerge. There...
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