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Lecture 25 0426 2012_class

Coming patients with lupus have excessive rate of

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Unformatted text preview: ertain cells especially the B and T lymphocytes lymphocytes In patients with lupus the disposal of the In apoptotic cells is defective apoptotic Moreover, the material that spills from apoptotic Moreover, cells is often abnormal cells Therefore, apoptotic cells are a potential Therefore, reservoir of auto-antigens that are capable of provoking an auto-antibody response provoking Genetic connection Genetic About 10% of patients with lupus have close About blood relatives with the disease blood It has been found that there is connection It between lupus and 48 chromosomal regions 6 of these regions on 5 different chromosomes of appear to be the most important appear Single genes are rarely, if ever, the primary Single driver driver Pathways and Therapeutic opportunities Pathways T-cell dependent activation Emerging therapies Emerging Blocking B7 molecules on antigen-presenting Blocking cells to avoid activation of helper T cells cells Directly disrupting the signaling between helper Directly T cells and B cells cells Anti-CD154 antibodies Anti-CD154 Interfering with B cell activity Decoy receptors which block B cell activating cytokines Reducing B cell numbers Reducing amount of anti-DNA antibodies Decoy DNA complexes Gene therapies, which would give cells the Gene ability to produce useful proteins themselves ability New drug discovery: microarrays microarrays ID of New Therapeutic Targets ID 1. Studies of gene expression profiles in Studies connection with family history of a disease. diseas...
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