Class Notes (1).pdf - [email protected] Midterm 1...

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[email protected] Midterm 1: October 11 (first 4 topics) - 30% - conflict time is at 7 AM the same day Midterm 2: November 1 (next 4 topics) - 30% Final Exam: TBD (final 5 topics) - 40% History of Drugs 2018 - 59 new drugs on the market - Lutathera and Erleada are newly released drugs used for treating cancer. - Approximately 35-40 new drugs get approved each year. Current Issues Martin Skrelli well known for raising the price of the antiparasitic, Daraprim, by 6000%. He was sentenced to prison and fines due to this scandal as CEO at the time. Sacklers is a family with a company with billions in sales of opioids where they were mislabeling their products, including those of fentanyl, codeine, oxycontin, and more. Opioids are amongst the highest causes of deaths in the US/Canada (most recently 70K) Asbestos seems to be present in baby powder causing a lot of concern around Johnson and Johnson. A tree in Chios, Greece, secretes a liquid; This tree grows and creates a limestone powder which can be ground up and reputed to cure/help/assist inflammation, wounds, ulcers, asthma, and more. Historical Issues Health issues were awfully treated as medicine and drugs were being developed. The physicians of the era lacked information and knowledge. They had things such as uroscopy flasks and wheels which would associate colouring with potential bodily issues; these were respectively accurate. Gas chromatography is the modern method of testing urine for different compounds. At the end of the last century the life expectancy for a man (North America) was 47. Now it is overall over 80 for men and women. Japan, France, Italy, Australia are amongst the countries with leading life expectancies. The world average is APPROX. 72. (the developed/industrialized countries are the leaders) Death rates for women while giving birth began to decrease around the time of WW2 when penicillin was discovered. The lowest point in life expectancy was around 1918 due to the influenza pandemic. When the world saw similar outbreaks vaccinations seemed to be minimally effective, still causing over half a million deaths. Eradicated Diseases - Smallpox - Polio
- Caused by poliovirus which can cause muscle weakness and paralysis. - Leprosy/Hansen’s Disease - Infectious disease causing severe, disfiguring skin sores and nerve damage. - Guinea Worm Disease/Dracunculiasis - a flea that lives in unfiltered/dirty water and enters the body when drinking water and makes it way through the skin. - Chagas Disease - Caused by the ‘kissing bug’ causing skin infections, rashes, swelling, and more. - Esophagus with a fungus growing; requires an antifungal drug - Balloon angioplasty also required to expand the cavity after fungi may be removed by the drug. What is a Drug? It is a chemical agent that affects living matter.

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