This preview shows page 1. Sign up to view the full content.
Unformatted text preview: embrane (fig. 11-25). Thus, if you
are a small molecule (say, ATP or ADP) you can move freely between the cytoplasm
and the IMS, so the IMS has a similar composition to the cytoplasm.
(2) The inner mitochondrial
membrane is very different: it has a
very high protein content, 75%
protein and, like bacterial membranes,
has no cholesterol. The integral
membrane proteins include a variety
of transporters, the proteins of the
electron transport chain, and ATP
synthase. The inner membrane is also
very impermeable to solutes but has
numerous transporters to manage the
exchange of specific molecules
between the MATRIX and the IMS.
The inner membrane is also deeply
and variably infolded, giving it a large
surface area relative to the size of the
mitochondrion. <Which stages of the total oxidation of glucose occur in mitochondria, and how are they organized?>
II. The TCA Cycle (everything here occurs in the mitochondrial matrix; see DVD 13-2!)
<here, the cell will harvest energy from coupled reactions at 6 steps out of 9 total (compare this to
(A) Harvesting high energy electrons (:H ions): move once through the cycle [Fig. 13-11]
(1) Recall that pyruvate (3C) is the product of glycolysis. It enters the TCA cycle in
an indirect way: it combines with coenzyme A (“CoA”) t...
View Full Document
- Fall '10
- cell biology