This preview shows page 1. Sign up to view the full content.
Unformatted text preview: o produce acetyl-coA (2C)
and 1 CO2. In this reaction, a pair of electrons (hydride ion) is transferred to NAD+ to
produce 1 NADH.
(2) Then, the 2 C’s of the acetyl group
enter the cycle by transfer to
oxaloacetate (4C) to produce citric acid
(3) Citrate is converted to isocitrate
(6C), with no recovery of energy.
(4) Isocitrate is then converted to áketoglutarate, yielding another pair of
electrons that reduce an NAD+ to
NADH, and producing another CO2.
(5) Next, á-ketoglutarate is converted to
succinyl-coA, which yields another pair
of electrons that reduce an NAD+ to
NADH and produces another CO2.
(6) Then succinyl-CoA is converted to
succinate; this reaction is coupled to the
synthesis of one GTP.
(7) Succinate is then converted to
fumarate, which yields a pair of
electrons that are harvested not by
NAD+, but by FADH (=> FADH2).
(8) Fumarate is converted to malate,
with no coupled reaction.
(9) Maleate is converted to
oxaloacetate, which yields a pair of
electrons that are harvested by NAD+ =>
NADH This returns the molecule that
we started with, which can continue the
cycle by combining with another
molecule of acetyl-CoA... (B) So what has happened here? Carbons in, high energy electrons out (see panel 13-2).
(1) A high energy 3-carbon compound (pyruvate) enters the matrix, a 2-carbon acetyl
group gets fed into the cycle and is systematica...
View Full Document
This note was uploaded on 06/12/2012 for the course BIOLOGY 231 taught by Professor Petethollenbeck during the Fall '10 term at Purdue.
- Fall '10
- cell biology