Lec18.respiration - BIOLOGY 325H Respiratory systems, Part...

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BIOLOGY 325H Respiratory systems, Part II Physiology of gas exchange February 27, 2008 The goal of respiration is to absorb O 2 from the surrounding environment to power oxidative metabolism, and to release from the body CO 2 that builds up as a wasteproduct of oxidative metabolism. The purpose of today’s lecture is to examine several aspects of mammalian respiratory physiology, and to appreciate how the biochemistry of gas exchange and transport have been adapted to insure that cells experiencing the highest levels of metabolic activity are adequately supplied with O 2 . Learning Goals 1. When blood leaves the pulmonary capillaries to return to the heart, it has reached equlibrium with the alveolar air with respect to the partial pressure of O 2 and CO 2 . Which two fluid compartments are at equilibrium? Where is hemoglobin located relative to these compartments, and how does it contribute (i) the distribution of O 2 at equilibrium, and (ii) the rate of O 2 diffusion into the blood? 2. What cells synthesize hemoglobin? How many polypeptide chains contribute to a single hemoglobin molecule? How many O 2 molecules can bind to a molecule of hemoglobin? What role does heme play in the structure and function of hemoglobin? 3. Learn to read and use binding curves (also called ‘dissociation curves’) such as the one presented in Sadava, Fig. 48.12. What parameters are shown on each of the two axes? What is a partial pressure? Learn to use this curve to predict – as a percentage - the
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This note was uploaded on 04/07/2008 for the course BIO 325H taught by Professor Staff during the Spring '08 term at University of Texas at Austin.

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Lec18.respiration - BIOLOGY 325H Respiratory systems, Part...

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