Lec04.Select - to break down ganglioside It accumulates in...

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1 Selection ± Under the null conditions of H-W, populations attain an equilibrium of both genotypic frequencies and gene frequencies. ± No evolution occurs under these conditions. ± We will consider simple mortality selection of different types ± Then consider selection on more complex, multi-locus traits Tay-Sachs Disease: Background ² Hex-A gene produces an enzyme that breaks down a fatty substance called ganglioside. ² As long as an individual inherits at least one copy of the normal gene, enough is produced to break down ganglioside. ² A double recessive condition leads to inability
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Unformatted text preview: to break down ganglioside It accumulates in neurons usually leading to death before age 3. Found at higher rates in French Canadians of southeastern Quebec and Cajuns of southern Louisiana and Ashkenazi Jews, but they carry a different mutation! Inferring selection from data Case study: resistance to DDT 2 3 Sickle-cell anemia Multilocus Selection Transition from single to multilocus selection 4 Example of multilocus selection Estimating the effects of selection Darwins Finches 5 Selection events Heritability Strength of selection...
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This note was uploaded on 04/07/2008 for the course BIO 325H taught by Professor Staff during the Spring '08 term at University of Texas at Austin.

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Lec04.Select - to break down ganglioside It accumulates in...

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