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Lec04.Select - to break down ganglioside ² It accumulates...

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1 Selection ± Under the null conditions of H-W, populations attain an equilibrium of both genotypic frequencies and gene frequencies. ± No evolution occurs under these conditions. ± We will consider simple mortality selection of different types ± Then consider selection on more complex, multi-locus traits Tay-Sachs Disease: Background ² Hex-A gene produces an enzyme that breaks down a fatty substance called ganglioside. ² As long as an individual inherits at least one copy of the normal gene, enough is produced to break down ganglioside. ² A double recessive condition leads to inability
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Unformatted text preview: to break down ganglioside ² It accumulates in neurons usually leading to death before age 3. ² Found at higher rates in French Canadians of southeastern Quebec and Cajuns of southern Louisiana and Ashkenazi Jews, but they carry a different mutation! Inferring selection from data ² Case study: resistance to DDT 2 3 Sickle-cell anemia Multilocus Selection Transition from single to multilocus selection 4 Example of multilocus selection Estimating the effects of selection Darwin’s Finches 5 Selection events Heritability Strength of selection...
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