Lec09.MolEvol - Molecular Evolution: The Foundation Look at...

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1 Molecular Evolution: The Foundation ± Look at some ways that the molecule of heredity can evolve to provide the variation central to evolution ± In a purely evolutionary context will lead us to ± Molecular clock ± Molecular phylogeny ± Neutral evolution ± This is an exciting field with lots of opportunities Beginning at the beginning: Point Mutation ± Definition : change of a single nucleotide from one base to another (substitution) ± Simple, but a lot to consider from the perspective of evolution ± Concentrate on how different point mutations are affected by drift and selection and how they can be modeled Types of Point Mutations ± Transitions ± Purine to purine (A, G) ± A G ± G A ± Pyrimidine to pyrimidine (C, T) ± C T ± T C ± Transversions ± Purine to pyrimidine ± Pyrimidine to purine (I’ll bet you can figure out the combinations without me writing them down.)
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2 A Model of Nucleotide Change ± Null hypothesis : equal probability that a base will
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This note was uploaded on 04/07/2008 for the course BIO 325H taught by Professor Staff during the Spring '08 term at University of Texas at Austin.

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Lec09.MolEvol - Molecular Evolution: The Foundation Look at...

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