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ProblemSet10 - ProblemSet10 MCB104Section105/106 1..f(Dpy...

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Problem Set 10 MCB 104 – Section 105/106 1. You are studying autosomal Dumpy and Unc mutations in a population of worms. f(Dpy‐) = .20 and f(Unc‐) = 0.4. After characterizing the haplotypes in 1000 worms you find the following frequencies: Haplotype # of Worms Dpy+;Unc+ 250 Dpy+;Unc‐ 250 Dpy‐; Unc+ 250 Dpy‐; Unc‐ 250 Are these two loci in linkage equilibrium? Why or why not? If not, what frequency would you predict for each haplotype? 2. The following table for sickle cell alleles was presented in class: Relative Fitness Genotype Non-Malarial Environment Malarial Environment AA 1.0 .89 AS 1.0 1.0 SS .2 .2 AC 1.0 .89 SC .71 .70 CC 1.0 1.3 Why is the C allele extremely rare in malarial environments even though CC individuals have a significant fitness advantage? Why is the S allele found mostly in African populations? A small population of AA individuals live on an island without malaria. The S and C alleles arise spontaneously by mutation in two different individuals. Which allele, if any, is more likely to go to fixation in this population?
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3. The diagram below represents a linkage map of 4 loci on a chromosome. The “X” marks a
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ProblemSet10 - ProblemSet10 MCB104Section105/106 1..f(Dpy...

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