note the rotor base and stator head and rotation f1

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: ADP~P bond(!) Note the rotor (base) and stator (head) and rotation F1 F0 Hypothesis: ADP + Pi ATP + H2O occurs on head; H+ flow turns rotor; rotor/rotation stimulates ATP release rotor rotation Figure 1 Observation system for the c subunit rotation in F0F1. Y Sambongi et al. Science 1999;286:1722-1724 Movie: Movie of the ATPase model -- Mechanical part of respiration. Model for H+-induced rotation from the textbook: What is the P:O ratio ? ATP formed: 1/2 O2 (2 e-) taken up For TCA cycle, early estimates: per NADH, 3; per succinate (FAD), 2 Best data: per NADH, 2.5; per succinate (FAD), 1.5 Book: 10 H+ per NADH, 4 H+ per ATP = 2.5 (Originally depended on an accurate measure of H+ flow, correcting for leaks across the membrane; now related to the Fo structure: 10 H+/NADH, 12 H+/Fo rotation, 3 ATP/Fo rotation) Recent evidence: H+/ATP varies from 12/3 (4) in animals to 15/3 (5) in microbes, depending on the number of Fo subunits in the Fo ring in the membran...
View Full Document

This note was uploaded on 08/30/2012 for the course BIS 105 taught by Professor Kennethhilt during the Spring '09 term at UC Davis.

Ask a homework question - tutors are online