Lecture's guest Feb_10_2012_Sequence_Based_typing_of_Legionella_spp

University of toronto february 10 2012 toronto

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Unformatted text preview: suggests that these clinical cases are unrelated. University of Toronto, February 10, 2012 Toronto, Outbreak investigations: Outbreak tracking the environmental source tracking PHU 22: PHU ST222 Clinical isolates (n=2) ST226 Environmental isolates (n=7) ST1 14%, ST59 14% PHU 18: PHU ST222 Environmental isolates (n=9) PHU 26: PHU Clinical isolates (n=7) ST226 ST1 Clinical isolates (n=1) ST154 Environmental isolates (n=6) ST154 72% ST1 Environmental isolates (n=17) 24% new ST PHU 4: Clinical isolates (n=1): 100% 76% 100 % 72 to 100% of correlation between ST# from clinical and environmental 72 ental isolates. isolates. University of Toronto, February 10, 2012 Toronto, Use of SBT to study the molecular evolution of pathogenic bacteria • • • • • Prevention of infectious diseases University of Toronto, February 10, 2012 Toronto, Phylogenetic Cluster analysis Group I 40 isolates (21%) Group II 112 isolates (58%) Group III 42 isolates (21%) Tijet et al, Emer. Infect. diseases, 2010 University of Toronto, February 10, 2012 Toronto, Group II average rates by Ontario Health Region (OHR) between 1990 to 2006. Rates Group II per Rates Health Region Health 0.000000 0.000001 - 0.005000 0.005001 - 0.010000 0.010001 - 0.021018 0.021019 - 0.500000 Tijet et al, Emerg. Infect. diseases, 2010 Average rates of group II isolates are more uniformly distributed in Ontario. University of Toronto, February 10, 2012 Toronto, Group I/III average rates by Ontario Health Region (OHR) between 1990 to 2006 Rates Group III per Rates Health Region Health 0.000000 0.000001 - 0.005000 0.005001 - 0.010000 0.010001 - 0.021018 0.021019 - 0.500000 Tijet et al, Emer. Infect. diseases, 2010 Average rates of group III isolates are higher in the southern Ontario Health Region. University of Toronto, February 10, 2012 Toronto, Genetic Variation in Bacterial Populations Cluster analysis using eBURST algorithm: Identifies mutually exclusive groups of related genotypes in a population. Identifies the founding genotype (sequence type or ST) of each group. Predicts the descent from the predicted founding genotype to the other genotypes in the group: Ancestral Type (AT). The procedure was developed for use with the d...
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