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Lecture's guest Feb_10_2012_Sequence_Based_typing_of_Legionella_spp

University of toronto february 10 2012 university

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Unformatted text preview: ata produced by MLST. University of Toronto, February 10, 2012 University Toronto, Cluster analysis using eBURST Clonal population with a founding genotype Non-clonal population with unlinked genotypes University of Toronto, February 10, 2012 Toronto, Comparative eBURST analyses Comparative eBURST analyses of Ontario and EWGLI STs STs ST276 Clonal Group A ST289 ST213 ST227 ST222 Unique to Ontario Common to Ontario and EWGLI databases Clonal group A is endemic to North America Tijet et al, Emer. Infect. diseases, 2010 University of Toronto, February 10, 2012 Toronto, Prevalence of a new North American endemic Clonal group in Ontario ST276 ST289 ST213 ST227 ST222 Clonal Group A Ratio endemic / total clinical strains 80 70 60 50 40 30 20 10 0 1980 1985 1990 1995 2000 2005 2010 Tijet et al, Emer. Infect. diseases, 2010 Increased prevalence of a North American endemic clonal group in Ontario University of Toronto, February 10, 2012 Toronto, Perspectives • Why is this specific clonal group endemic to North America? • Is it adapted to our environment? • Is it more virulent than reference strains? • Why did it recently emerged? • Experimental Strategy : • Comparative genomic analysis (New generation sequencing methods). • Comparative analysis of virulence using in vitro and in vivo models. PHO PHO NIH-NIAID Carla Duncan Dr. Nathalie Tijet Dr. Julia Mallegol Akriti Prashar (PhD student) Jannice So Patrick Tang Dr. Tom Schwan Universities in USA Dr. Craig Roy Dr. Paul Hoffman Dr. Raphael Garduno University of Toronto Pasteur Institute Dr Mauricio terebeznik Dr. Camille Locht Dr. Franco Menozzi Funding Sympolegio, Nov 16, 2011...
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