Unformatted text preview: ata produced by MLST. University of Toronto, February 10, 2012
University Toronto, Cluster analysis using
eBURST Clonal population
with a founding genotype Non-clonal population
with unlinked genotypes University of Toronto, February 10, 2012
Toronto, Comparative eBURST analyses
Comparative eBURST analyses
of Ontario and EWGLI STs
ST276 Clonal Group A ST289
ST213 ST227 ST222 Unique to Ontario
Common to Ontario and EWGLI databases Clonal group A is endemic to North America Tijet et al, Emer. Infect. diseases, 2010 University of Toronto, February 10, 2012
Toronto, Prevalence of a new North American
endemic Clonal group in Ontario ST276
ST213 ST227 ST222 Clonal Group A Ratio endemic / total clinical strains 80
0 1980 1985 1990 1995 2000 2005 2010 Tijet et al, Emer. Infect. diseases, 2010 Increased prevalence of a North American endemic clonal group in Ontario
University of Toronto, February 10, 2012
• Why is this specific clonal group endemic to North America?
• Is it adapted to our environment?
• Is it more virulent than reference strains?
• Why did it recently emerged? • Experimental Strategy :
• Comparative genomic analysis (New generation sequencing methods).
• Comparative analysis of virulence using in vitro and in vivo models. PHO
PHO NIH-NIAID Carla Duncan
Dr. Nathalie Tijet
Dr. Julia Mallegol
Akriti Prashar (PhD student)
Patrick Tang Dr. Tom Schwan
Universities in USA
Dr. Craig Roy
Dr. Paul Hoffman
Dr. Raphael Garduno University of Toronto Pasteur Institute Dr Mauricio terebeznik Dr. Camille Locht
Dr. Franco Menozzi
Funding Sympolegio, Nov 16, 2011...
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- Spring '12