Lecture's guest Feb_10_2012_Sequence_Based_typing_of_Legionella_spp

Pneumophila brieland j m et al infect immun 654892 6

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Unformatted text preview: ide amoebae has been shown to enhance the virulence of L. pneumophila (Brieland, J., M. et al Infect Immun 65:4892-6 .) University of Toronto, February 10, 2012 Toronto, Source of infections • What are the water sources for Legionnaires' disease? The major sources are water distribution systems of large buildings including hotels and hospitals. Cooling towers. Other sources include mist machines, humidifiers, whirlpool spas, hot springs and Air conditioners. • How do people contract Legionella? The organism is aerosolized in water and people inhale the droplets containing Legionella. University of Toronto, February 10, 2012 Toronto, Diagnostics Laboratory methods to diagnose legionellosis. Guyard C. and Low DE., Travel Med Infect Dis. 2011 University of Toronto, February 10, 2012 Toronto, Epidemiology of legionellosis in Ontario Europe 140 120 100 80 60 40 20 0 19 92 19 94 19 96 19 98 20 00 20 02 20 04 20 06 20 08 20 10 Number of legionellosis cases Ontario Years University of Toronto, February 10, 2012 Toronto, Seasonality of legionellosis in Ontario: 2006-2011 University of Toronto, February 10, 2012 Toronto, • • • “ ” • • • “ ” • • … • • University of Toronto, February 10, 2012 University Toronto, What is the source of infection? Isolated cases Source(s) of the infection? Source 1 Source 2 Source 3 Match Timely intervention to prevent further infections University of Toronto, February 10, 2012 Toronto, Are we facing an oubreak? Is there a common source? Suspected outbreak Yes or No Source(s) of the outbreak? Freshwater sources (80%) Source 1 Source 2 Source 3 Match Timely intervention to prevent further infections University of Toronto, February 10, 2012 Toronto, Why do we need molecular typing data? Suspected outbreak Isolated cases Source(s) of the infection? Source(s) of the outbreak? suspected sources Source 1 Source 2 Source 3 Necessary to obtain subtyping data. University of Toronto, February 10, 2012 Toronto, Available Typing Methods Methods Guyard C. and Low DE., Travel Med Infect Dis. 2011 University of Toronto, February 10, 2012 Toronto, Advantages of Sequence Based Typing. • Robust, reliable. • Reproducible. • Portable: Allows compar...
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This note was uploaded on 09/16/2012 for the course MICROBIOLO 101 taught by Professor Tom during the Spring '12 term at Arab Open University, Amman.

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