Streptococcus

Streptococcus - Streptococcus 02/04/08 02/08/08 I)...

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Streptococcus Flores, 1 02/04/08 – 02/08/08 MCDB 132 I)  Classification - Gram +, non-motile, facultative anaerobe (aerobic) - A) RBC hemolysis 1)  hemolysis (green)  α  partial (S. pneumoniae) 2)  hemolysis (halo)  β  full hemolysis 3)  hemolysis  γ  none (Enterococcus) hard to treat because so resistant B) Serology   cell wall polysaccharide antigens 1) Lance field grouping   GAS, GBS, GDS Isolated antigens for each group II) Group A Streptococcus (GAS)           S. pyrogenes     - forms chains - pyogenic = puss forming  -  hemolytic  β - causes strep throat, tonsillitis - post streptococcal sequetae o Rheumatic fever (makes Abs that resemble heart cells) ** Most common Streptococcal infection of humans A) Reservoir     1) B) Diseases     1) Strep throat, impetigo (skin), ear infection 2) Necrotizing fasciitis   flesh eating bacteria (a) TSLS   endocarditis, meningitis, pneumonia, rheumatic fever C) Pathogenesis     1) Initial colonization of urinary tract (URT) or middle ear   otitis media 2) Pneumonia   LRT 3) Meningitis   spread from otitis media or pneumonia via bloodstream 4) Wound   necrotizing fasciitis, TSLS
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Streptococcus Flores, 2 02/04/08 – 02/08/08 MCDB 132 D) Virulence Factors     1) Adhesins   binding/camouflage (a) M protein – binds to extracellular matrix (fimbriae)  (i) Epitopes to heart muscle   induces rheumatic fever Treat strep throat with Antibiotics 2) Extracellular products (a) Leukocidins 
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Streptococcus - Streptococcus 02/04/08 02/08/08 I)...

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