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Unformatted text preview: Checkpoint
3. Metaphase Checkpoint
What is the function of the G1 CHECKPOINT ? ensures cell is big enough to divide
has enough nutrients
dna is not damaged
What would happen if the G1 checkpoint FAILED ? FAIL TO DIVIDE
What is the function of the G2 CHECKPOINT ? ensures S phase (replication)
What would happen if the G2 checkpoint FAILED ? daughters NOT HAVE SAME CHROMOSOMES
What is the function of the Metaphase CHECKPOINT ? ensures chromosomes are attached to spindle via kinetochore 8
What would happen if the Metaphase checkpoint FAILED ? daughter cells have wrong number of chromosomes
CANCER : OUT OF CONTROL CELL DIVISION
Fig. 11.16 Changes in Cancer Rates over Time
In cancer cells, how is cell division different from that which occurs in normal dividing cells ? uncontrolled cell division
cancer cells divide faster than normal
cell cycle is not regulated
cell cycle checkpoints fail
- spread (movement) of cancerous cells from their original growth site to other organs
Fig. 11.17 Cancers May Spread to...
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This note was uploaded on 10/14/2012 for the course ASTRO 1f03 taught by Professor Perkins during the Spring '12 term at McMaster University.
- Spring '12