Week 4 (Sept 29 - Oct 5) Chp 11 Lectures & Supplementary Information (Blanks)

G1 checkpoint 2 g2 checkpoint 3 metaphase checkpoint

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Unformatted text preview: Checkpoint 3. Metaphase Checkpoint What is the function of the G1 CHECKPOINT ? ensures cell is big enough to divide has enough nutrients dna is not damaged What would happen if the G1 checkpoint FAILED ? FAIL TO DIVIDE What is the function of the G2 CHECKPOINT ? ensures S phase (replication) succeeded What would happen if the G2 checkpoint FAILED ? daughters NOT HAVE SAME CHROMOSOMES What is the function of the Metaphase CHECKPOINT ? ensures chromosomes are attached to spindle via kinetochore 8 What would happen if the Metaphase checkpoint FAILED ? daughter cells have wrong number of chromosomes CANCER : OUT OF CONTROL CELL DIVISION Fig. 11.16 Changes in Cancer Rates over Time In cancer cells, how is cell division different from that which occurs in normal dividing cells ? uncontrolled cell division cancer cells divide faster than normal cells cell cycle is not regulated cell cycle checkpoints fail METASTASIS - spread (movement) of cancerous cells from their original growth site to other organs Fig. 11.17 Cancers May Spread to...
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